Luigi M E Grimaldi obtained his MD and board certification in neurology at the University of Catania (Italy). He was research fellow in neuroimmunology at the Department of Neurology of the Pritzker School of Medicine of the University of Chicago. In 1988, he joined the Department of Neurology of the Istituto San Raffaele of Milano as a Clinical and Research Assistant, and then Associate. In 1992 he founded the Neuroimmunology Unit of the Department of Biotechnology (DIBIT), which he ran until 2000. He is currently Head of Neurology at the Fondazione Istituto San Raffaele “G Giglio” of Cefalù (Italy) where he runs a multiple sclerosis clinic, a dementia center and a stroke unit involved in over 50 pharmaceutical clinical trials. His main research interests are the neuroimmunological basis of chronic, degenerative and infectious neurological diseases, including multiple sclerosis, Alzheimer’s disease, herpes simplex virus encephalitis, and myasthenia gravis. His work has resulted in 150 peer-reviewed journal articles.