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Table 1 Differentially expressed genes between clinically stable MS, active MS and controls by DNA array analysis (Additional file 1)

From: Increased expression of dedicator-cytokinesis-10, caspase-2 and Synaptotagmin-like 2 is associated with clinical disease activity in multiple sclerosis

Cluster

Gene symbol

p-value

Description

Cluster #1

TNPO1

2.00E-07

Transportin 1

CXCR3

0.0009282

Chemokine (C-X-C motif) receptor 3

ATP9A

0.0007041

ATPase, Class II, type 9A

CASP2

0.0003848

Caspase 2

PRX

0.0009587

Periaxin

DSP

0.0006427

Desmoplakin

MALAT1

0.0009593

Metastasis associated lung adenocarcinoma transcript 1; PRO1073

CXorf56

0.0001169

chromosome X open reading frame 56, hypothetical protein FLJ22965

SSBP4

2.07E-05

single stranded DNA binding protein 4

CCT8

2.13E-05

Chaperonin containing TCP1, subunit 8 (theta)

 

9.61E-05

Homo sapiens cDNA clone IMAGE:4824925

ELSPBP1

0.0006039

Epididymal sperm binding protein 1

Cluster #2

DOCK10

0.0003135

Dedicator of cytokinesis 10

Cluster #3

ZNF75

0.0005587

Zinc finger protein 75 (D8C6)

MRS2L

0.0007168

MRS2-like, magnesium homeostasis factor (S. cerevisiae)

TTC10

0.0006527

Tetratricopeptide repeat domain 10, IFT88: intraflagellar transport 88

 

0.0002011

Homo sapiens cDNA clone IMAGE:2348094 3

MIA3

0.0004529

Melanoma inhibitory activity family, member 3, C219-reactive peptide

KMO

7.40E-06

Kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)

FREB

1.19E-05

Fc receptor homolog expressed in B cells; FCRLA

MRPL16

0.0005844

Mitochondrial ribosomal protein L16

RNFT1

0.0004832

ring finger protein, transmembrane 1; PTD016 protein

PRO1693

0.0002505

Homo sapiens PRO1693 protein

ANXA4

0.0002741

Annexin A4

MTM1

0.0004095

Myotubularin 1

KLHDC5

0.0004232

Kelch domain containing 5; KIAA1340 protein

METTL21A

0.0004554

Methyltransferase like 21A

RBBP4

0.0003732

Retinoblastoma binding protein 4

PPP2CB

0.0008942

Protein phosphatase 2, catalytic subunit, beta isoform

TRAPPC11

0.0003224

Trafficking protein particle complex subunit 11 isoform a

SLC7A7

0.0008726

Solute carrier family 7 (cationic amino acid transporter, y + system)

ALG13

0.0005845

Asparagine-linked glycosylation 13 homolog; chromosome X ORF45

PDIA3

0.000489

Protein disulfide isomerase family A; glucose regulated protein, 58 kDa

INPP4A

0.0007406

Inositol polyphosphate-4-phosphatase, type I, 107 kDa

TFEC

0.0002318

Transcription factor EC

DDX23

0.0006295

DEAD (Asp-Glu-Ala-Asp) box polypeptide 23

KIFAP3

0.0003059

Kinesin-associated protein 3

NEK4

0.0002713

NIMA (never in mitosis gene a)-related kinase 4

Cluster #4

ZNF24

0.0009911

Zinc finger protein 24 (KOX 17)

BTBD7

6.14E-05

BTB (POZ) domain containing 7

ITPR1

0.0003003

Inositol 1,4,5-triphosphate receptor, type 1

WDR20

1.07E-05

WD repeat domain 20

LOC100507376

3.00E-07

CDNA FLJ90295 fis, clone NT2RP2000240.

SYTL2

0.0002614

Synaptotagmin-like 2

ARHGEF7

0.0003018

Rho guanine nucleotide exchange factor (GEF) 7

  1. We identified 45 DEGs between stable MS, active MS and healthy controls (F-test, FDR corrected p-value). Cluster analysis grouped the DEG in 4 clusters. Genes validated in the second cohort are highlighted in bold
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Multiple Sclerosis and Demyelinating Disorders

ISSN: 2056-6115

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