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Table 1 Differentially expressed genes between clinically stable MS, active MS and controls by DNA array analysis (Additional file 1)

From: Increased expression of dedicator-cytokinesis-10, caspase-2 and Synaptotagmin-like 2 is associated with clinical disease activity in multiple sclerosis

Cluster Gene symbol p-value Description
Cluster #1 TNPO1 2.00E-07 Transportin 1
CXCR3 0.0009282 Chemokine (C-X-C motif) receptor 3
ATP9A 0.0007041 ATPase, Class II, type 9A
CASP2 0.0003848 Caspase 2
PRX 0.0009587 Periaxin
DSP 0.0006427 Desmoplakin
MALAT1 0.0009593 Metastasis associated lung adenocarcinoma transcript 1; PRO1073
CXorf56 0.0001169 chromosome X open reading frame 56, hypothetical protein FLJ22965
SSBP4 2.07E-05 single stranded DNA binding protein 4
CCT8 2.13E-05 Chaperonin containing TCP1, subunit 8 (theta)
  9.61E-05 Homo sapiens cDNA clone IMAGE:4824925
ELSPBP1 0.0006039 Epididymal sperm binding protein 1
Cluster #2 DOCK10 0.0003135 Dedicator of cytokinesis 10
Cluster #3 ZNF75 0.0005587 Zinc finger protein 75 (D8C6)
MRS2L 0.0007168 MRS2-like, magnesium homeostasis factor (S. cerevisiae)
TTC10 0.0006527 Tetratricopeptide repeat domain 10, IFT88: intraflagellar transport 88
  0.0002011 Homo sapiens cDNA clone IMAGE:2348094 3
MIA3 0.0004529 Melanoma inhibitory activity family, member 3, C219-reactive peptide
KMO 7.40E-06 Kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
FREB 1.19E-05 Fc receptor homolog expressed in B cells; FCRLA
MRPL16 0.0005844 Mitochondrial ribosomal protein L16
RNFT1 0.0004832 ring finger protein, transmembrane 1; PTD016 protein
PRO1693 0.0002505 Homo sapiens PRO1693 protein
ANXA4 0.0002741 Annexin A4
MTM1 0.0004095 Myotubularin 1
KLHDC5 0.0004232 Kelch domain containing 5; KIAA1340 protein
METTL21A 0.0004554 Methyltransferase like 21A
RBBP4 0.0003732 Retinoblastoma binding protein 4
PPP2CB 0.0008942 Protein phosphatase 2, catalytic subunit, beta isoform
TRAPPC11 0.0003224 Trafficking protein particle complex subunit 11 isoform a
SLC7A7 0.0008726 Solute carrier family 7 (cationic amino acid transporter, y + system)
ALG13 0.0005845 Asparagine-linked glycosylation 13 homolog; chromosome X ORF45
PDIA3 0.000489 Protein disulfide isomerase family A; glucose regulated protein, 58 kDa
INPP4A 0.0007406 Inositol polyphosphate-4-phosphatase, type I, 107 kDa
TFEC 0.0002318 Transcription factor EC
DDX23 0.0006295 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
KIFAP3 0.0003059 Kinesin-associated protein 3
NEK4 0.0002713 NIMA (never in mitosis gene a)-related kinase 4
Cluster #4 ZNF24 0.0009911 Zinc finger protein 24 (KOX 17)
BTBD7 6.14E-05 BTB (POZ) domain containing 7
ITPR1 0.0003003 Inositol 1,4,5-triphosphate receptor, type 1
WDR20 1.07E-05 WD repeat domain 20
LOC100507376 3.00E-07 CDNA FLJ90295 fis, clone NT2RP2000240.
SYTL2 0.0002614 Synaptotagmin-like 2
ARHGEF7 0.0003018 Rho guanine nucleotide exchange factor (GEF) 7
  1. We identified 45 DEGs between stable MS, active MS and healthy controls (F-test, FDR corrected p-value). Cluster analysis grouped the DEG in 4 clusters. Genes validated in the second cohort are highlighted in bold