Table 1 Absolute and relative contraindications of Alemtuzumab

Hypersensitivity to the active substance, or to any of the excipients.

Severe active infections. Additionally, this drug should not be used in the presence of active chronic or recurrent bacterial or viral infections, such as TB, HCV. HBV or HIV.

Pregnancy or lactation.

Relative contraindication

Blood coagulation disorders such as dysfibrinoginemia, factor IX deficiency, hemophilia, von Willebrandt disease, or anti-coagulation therapy.

Significant infection liability, such as aspiration susceptibility or frequent urinary tract infection.

Malignant diseases in the patient history, which is not curatively treated.

Thrombocytopenia.

Negative Varicella-zoster IgG status

Severe liver or kidney insufficiency

Children under 18 years of age