All patients (n = 69) | Group A - no relapses or EDSS progression during first 5 years of GA therapy (n = 32) | Group B - with relapses and/or EDSS progression during first 5 years of GA therapy (n = 37) | ||
---|---|---|---|---|
Age at GA start | 33.0 (0.9) | 31.8 (1.1) | 34.1 (1,2) | |
Sex (females %) | 50 (72.5) | 20 (62.5) | 30 (81.1) | |
MS duration at GA start, years | 5.43 (0.44) | 5.50 (0.72) | 5.38 (0,61) | |
Baseline | ARR | 2.15 (0.06) | 2.05 (0,08) | 2.24 (0,09) |
EDDS | 2.11 (0.10) 1-5 | 2.07 (0,10) | 2.15 (0,11) | |
Year 1 | ARR | 0.06 (0.04) | 0 | 0.10 (0.04) |
EDSS | 1.93 (0.09) 1-5 | 1.92 (0.14) | 2.03 (0.12) | |
Year 2 | ARR | 0.06 (0.04) | 0 | 0.12 (0.05) |
EDSS | 1.95 (0.10) 1-4 | 1.88 (0.14) | 2.09 (0.14) | |
Year 3 | ARR | 0.08 (0.04) | 0 | 0.16 (0.06) |
EDSS | 2.01 (0.10) 0-4 | 1.91 (0.14) | 2.21 (0.15) | |
Year 4 | ARR | 0.13 (0.04) | 0 | 0.22 (0.07) |
EDSS | 2.14 (0.11) 0-4 | 2.05 (0.16) | 2.44 (0.17) | |
Year 5 | ARR | 0.14 (0.05) | 0 | 0.26 (0.07) |
EDSS | 2.19 (0.12) 0-5 | 2.02 (0.16) | 2.53 (0.17) * | |
Year 6 | ARR | 0.16 (0.04) | 0.05 (0,03) | 0.25 (0.07) * |
EDSS | 2.22 (0.12) 1-5 | 1.98 (0.16) | 2.61 (0.18) * ** | |
Year 7 | ARR | 0.17 (0.05) | 0.06 (0,03) | 0.30 (0.07) * |
EDSS | 2.27 (0.13) 1-5 | 2.00 (0.16) | 2.70 (0.18) * ** | |
Year 8 | ARR | 0.16 (0.04) | 0.05 (0,03) | 0.25 (0.06) * |
EDSS | 2.34 (0.13) 1-5 | 1.98 (0.16) | 2.84 (0.18) * ** | |
Year 9 | ARR | 0.15 (0.04) | 0.06 (0,03) | 0.23 (0.07) * |
EDSS | 2.42 (0.14) 1-5 | 1.97 (0.16) | 3.00 (0.21) * ** | |
Year 10 | ARR | 0.15 (0.04) | 0.08 (0,03) | 0.24 (0.07) |
EDSS | 2.53 (0.16) 1-5.5 ** | 2.05 (0.17) | 3.17 (0.23) * ** | |
Year 11 | ARR | 0.18 (0.05) | 0.06 (0,03) | 0.31 (0.09) * |
EDSS | 2.56 (0.15) 1-5,5 ** | 2.00 (0.15) | 3.20 (0.22) * ** | |
Year 12 | ARR | 0.16 (0.04) | 0.08 (0,03) | 0.26 (0.07) * |
EDSS | 2.66 (0.16) 1-5.5.** | 2.00 (0.15) | 3.37 (0.23) * ** | |
Year 13 | ARR | 0.21 (0.06) | 0.12 (0,04) | 0.36 (0.10) * |
EDSS | 2.82 (0.16) 1-6 ** | 2.09 (0.14) | 3.59 (0.23) * ** | |
Year 14 | ARR | 0.17 (0.05) | 0.12 (0,04) | 0.25 (0.08) |
EDSS | 3.03 (0.16) 1-6 ** | 2.23 (0.14) | 3.87 (0.22) * ** | |
Year 15 | ARR | 0.13 (0.04) | 0.06 (0,03) | 0.21 (0.08) |
EDSS | 3.26 (0.18) 1-6.5 ** | 2.27 (0.14) | 4.26 (0.23) * ** | |
Mean ARR for 15 years | 0,15 (0.05) | 0,07 (0.03) | 0,22 (0.06) * | |
Mean Δ EDSS for 15 years | 1,15 (0.09) | 0.20 (0.06) | 2.11 (0.12) * |