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Table 2 Mean annual relapse rate (ARR) and EDSS score (mean (SD) plus intervals) changes stratified by the presence or absence of relapses or EDSS progression during the first 5 years of GA treatment

From: Long-term results of the first line DMT depend on the presence of minimal MS activity during first years of therapy: data of 15 years observation

  All patients (n = 69) Group A - no relapses or EDSS progression during first 5 years of GA therapy (n = 32) Group B - with relapses and/or EDSS progression during first 5 years of GA therapy (n = 37)
Age at GA start 33.0 (0.9) 31.8 (1.1) 34.1 (1,2)
Sex (females %) 50 (72.5) 20 (62.5) 30 (81.1)
MS duration at GA start, years 5.43 (0.44) 5.50 (0.72) 5.38 (0,61)
Baseline ARR 2.15 (0.06) 2.05 (0,08) 2.24 (0,09)
EDDS 2.11 (0.10) 1-5 2.07 (0,10) 2.15 (0,11)
Year 1 ARR 0.06 (0.04) 0 0.10 (0.04)
EDSS 1.93 (0.09) 1-5 1.92 (0.14) 2.03 (0.12)
Year 2 ARR 0.06 (0.04) 0 0.12 (0.05)
EDSS 1.95 (0.10) 1-4 1.88 (0.14) 2.09 (0.14)
Year 3 ARR 0.08 (0.04) 0 0.16 (0.06)
EDSS 2.01 (0.10) 0-4 1.91 (0.14) 2.21 (0.15)
Year 4 ARR 0.13 (0.04) 0 0.22 (0.07)
EDSS 2.14 (0.11) 0-4 2.05 (0.16) 2.44 (0.17)
Year 5 ARR 0.14 (0.05) 0 0.26 (0.07)
EDSS 2.19 (0.12) 0-5 2.02 (0.16) 2.53 (0.17) *
Year 6 ARR 0.16 (0.04) 0.05 (0,03) 0.25 (0.07) *
EDSS 2.22 (0.12) 1-5 1.98 (0.16) 2.61 (0.18) * **
Year 7 ARR 0.17 (0.05) 0.06 (0,03) 0.30 (0.07) *
EDSS 2.27 (0.13) 1-5 2.00 (0.16) 2.70 (0.18) * **
Year 8 ARR 0.16 (0.04) 0.05 (0,03) 0.25 (0.06) *
EDSS 2.34 (0.13) 1-5 1.98 (0.16) 2.84 (0.18) * **
Year 9 ARR 0.15 (0.04) 0.06 (0,03) 0.23 (0.07) *
EDSS 2.42 (0.14) 1-5 1.97 (0.16) 3.00 (0.21) * **
Year 10 ARR 0.15 (0.04) 0.08 (0,03) 0.24 (0.07)
EDSS 2.53 (0.16) 1-5.5 ** 2.05 (0.17) 3.17 (0.23) * **
Year 11 ARR 0.18 (0.05) 0.06 (0,03) 0.31 (0.09) *
EDSS 2.56 (0.15) 1-5,5 ** 2.00 (0.15) 3.20 (0.22) * **
Year 12 ARR 0.16 (0.04) 0.08 (0,03) 0.26 (0.07) *
EDSS 2.66 (0.16) 1-5.5.** 2.00 (0.15) 3.37 (0.23) * **
Year 13 ARR 0.21 (0.06) 0.12 (0,04) 0.36 (0.10) *
EDSS 2.82 (0.16) 1-6 ** 2.09 (0.14) 3.59 (0.23) * **
Year 14 ARR 0.17 (0.05) 0.12 (0,04) 0.25 (0.08)
EDSS 3.03 (0.16) 1-6 ** 2.23 (0.14) 3.87 (0.22) * **
Year 15 ARR 0.13 (0.04) 0.06 (0,03) 0.21 (0.08)
EDSS 3.26 (0.18) 1-6.5 ** 2.27 (0.14) 4.26 (0.23) * **
Mean ARR for 15 years 0,15 (0.05) 0,07 (0.03) 0,22 (0.06) *
Mean Δ EDSS for 15 years 1,15 (0.09) 0.20 (0.06) 2.11 (0.12) *
  1. EDSS expanded disability status score
  2. * - significantly in comparison to Group A with p < 0.05
  3. ** significantly in comparison with baseline level with p < 0.05