Skip to main content

Table 2 Mean annual relapse rate (ARR) and EDSS score (mean (SD) plus intervals) changes stratified by the presence or absence of relapses or EDSS progression during the first 5 years of GA treatment

From: Long-term results of the first line DMT depend on the presence of minimal MS activity during first years of therapy: data of 15 years observation

 

All patients (n = 69)

Group A - no relapses or EDSS progression during first 5 years of GA therapy (n = 32)

Group B - with relapses and/or EDSS progression during first 5 years of GA therapy (n = 37)

Age at GA start

33.0 (0.9)

31.8 (1.1)

34.1 (1,2)

Sex (females %)

50 (72.5)

20 (62.5)

30 (81.1)

MS duration at GA start, years

5.43 (0.44)

5.50 (0.72)

5.38 (0,61)

Baseline

ARR

2.15 (0.06)

2.05 (0,08)

2.24 (0,09)

EDDS

2.11 (0.10) 1-5

2.07 (0,10)

2.15 (0,11)

Year 1

ARR

0.06 (0.04)

0

0.10 (0.04)

EDSS

1.93 (0.09) 1-5

1.92 (0.14)

2.03 (0.12)

Year 2

ARR

0.06 (0.04)

0

0.12 (0.05)

EDSS

1.95 (0.10) 1-4

1.88 (0.14)

2.09 (0.14)

Year 3

ARR

0.08 (0.04)

0

0.16 (0.06)

EDSS

2.01 (0.10) 0-4

1.91 (0.14)

2.21 (0.15)

Year 4

ARR

0.13 (0.04)

0

0.22 (0.07)

EDSS

2.14 (0.11) 0-4

2.05 (0.16)

2.44 (0.17)

Year 5

ARR

0.14 (0.05)

0

0.26 (0.07)

EDSS

2.19 (0.12) 0-5

2.02 (0.16)

2.53 (0.17) *

Year 6

ARR

0.16 (0.04)

0.05 (0,03)

0.25 (0.07) *

EDSS

2.22 (0.12) 1-5

1.98 (0.16)

2.61 (0.18) * **

Year 7

ARR

0.17 (0.05)

0.06 (0,03)

0.30 (0.07) *

EDSS

2.27 (0.13) 1-5

2.00 (0.16)

2.70 (0.18) * **

Year 8

ARR

0.16 (0.04)

0.05 (0,03)

0.25 (0.06) *

EDSS

2.34 (0.13) 1-5

1.98 (0.16)

2.84 (0.18) * **

Year 9

ARR

0.15 (0.04)

0.06 (0,03)

0.23 (0.07) *

EDSS

2.42 (0.14) 1-5

1.97 (0.16)

3.00 (0.21) * **

Year 10

ARR

0.15 (0.04)

0.08 (0,03)

0.24 (0.07)

EDSS

2.53 (0.16) 1-5.5 **

2.05 (0.17)

3.17 (0.23) * **

Year 11

ARR

0.18 (0.05)

0.06 (0,03)

0.31 (0.09) *

EDSS

2.56 (0.15) 1-5,5 **

2.00 (0.15)

3.20 (0.22) * **

Year 12

ARR

0.16 (0.04)

0.08 (0,03)

0.26 (0.07) *

EDSS

2.66 (0.16) 1-5.5.**

2.00 (0.15)

3.37 (0.23) * **

Year 13

ARR

0.21 (0.06)

0.12 (0,04)

0.36 (0.10) *

EDSS

2.82 (0.16) 1-6 **

2.09 (0.14)

3.59 (0.23) * **

Year 14

ARR

0.17 (0.05)

0.12 (0,04)

0.25 (0.08)

EDSS

3.03 (0.16) 1-6 **

2.23 (0.14)

3.87 (0.22) * **

Year 15

ARR

0.13 (0.04)

0.06 (0,03)

0.21 (0.08)

EDSS

3.26 (0.18) 1-6.5 **

2.27 (0.14)

4.26 (0.23) * **

Mean ARR for 15 years

0,15 (0.05)

0,07 (0.03)

0,22 (0.06) *

Mean Δ EDSS for 15 years

1,15 (0.09)

0.20 (0.06)

2.11 (0.12) *

  1. EDSS expanded disability status score
  2. * - significantly in comparison to Group A with p < 0.05
  3. ** significantly in comparison with baseline level with p < 0.05