TY - JOUR AU - Imitola, J. AU - Chitnis, T. AU - Khoury, S. J. PY - 2005 DA - 2005// TI - Cytokines in multiple sclerosis: from bench to bedside JO - Pharmacol Ther VL - 106 UR - https://doi.org/10.1016/j.pharmthera.2004.11.007 DO - 10.1016/j.pharmthera.2004.11.007 ID - Imitola2005 ER - TY - JOUR AU - Martins, T. B. AU - Rose, J. W. AU - Jaskowski, T. D. AU - Wilson, A. R. AU - Husebye, D. AU - Seraj, H. S. PY - 2011 DA - 2011// TI - Analysis of proinflammatory and anti-inflammatory cytokine serum concentrations in patients with multiple sclerosis by using a multiplexed immunoassay JO - Am J Clin Pathol VL - 136 UR - https://doi.org/10.1309/AJCP7UBK8IBVMVNR DO - 10.1309/AJCP7UBK8IBVMVNR ID - Martins2011 ER - TY - JOUR AU - Chen, Y. C. AU - Chen, S. D. AU - Miao, L. AU - Liu, Z. G. AU - Li, W. AU - Zhao, Z. X. PY - 2012 DA - 2012// TI - Serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with multiple sclerosis JO - J Neuroimmunol VL - 243 UR - https://doi.org/10.1016/j.jneuroim.2011.12.008 DO - 10.1016/j.jneuroim.2011.12.008 ID - Chen2012 ER - TY - JOUR AU - Trojano, M. AU - Liguori, M. AU - Bosco Zimatore, G. AU - Bugarini, R. AU - Avolio, C. AU - Paolicelli, D. PY - 2002 DA - 2002// TI - Age-related disability in multiple sclerosis JO - Ann Neurol VL - 51 UR - https://doi.org/10.1002/ana.10147 DO - 10.1002/ana.10147 ID - Trojano2002 ER - TY - JOUR AU - Gorman, M. P. AU - Healy, B. C. AU - Polgar-Turcsanyi, M. AU - Chitnis, T. PY - 2009 DA - 2009// TI - Increased relapse rate in pediatric-onset compared with adult-onset multiple sclerosis JO - Arch Neurol VL - 66 UR - https://doi.org/10.1001/archneurol.2008.505 DO - 10.1001/archneurol.2008.505 ID - Gorman2009 ER - TY - JOUR AU - Chabas, D. AU - Ness, J. AU - Belman, A. AU - Yeh, E. A. AU - Kuntz, N. AU - Gorman, M. P. PY - 2010 DA - 2010// TI - Younger children with MS have a distinct CSF inflammatory profile at disease onset JO - Neurology VL - 74 UR - https://doi.org/10.1212/WNL.0b013e3181ce5db0 DO - 10.1212/WNL.0b013e3181ce5db0 ID - Chabas2010 ER - TY - JOUR AU - Chabas, D. AU - Castillo-Trivino, T. AU - Mowry, E. M. AU - Strober, J. B. AU - Glenn, O. A. AU - Waubant, E. PY - 2008 DA - 2008// TI - Vanishing MS T2-bright lesions before puberty: a distinct MRI phenotype? JO - Neurology VL - 71 UR - https://doi.org/10.1212/01.wnl.0000326896.66714.ae DO - 10.1212/01.wnl.0000326896.66714.ae ID - Chabas2008 ER - TY - JOUR AU - Renoux, C. AU - Vukusic, S. AU - Mikaeloff, Y. AU - Edan, G. AU - Clanet, M. AU - Dubois, B. PY - 2007 DA - 2007// TI - Natural history of multiple sclerosis with childhood onset JO - N Engl J Med VL - 356 UR - https://doi.org/10.1056/NEJMoa067597 DO - 10.1056/NEJMoa067597 ID - Renoux2007 ER - TY - JOUR AU - Banwell, B. AU - Bar-Or, A. AU - Cheung, R. AU - Kennedy, J. AU - Krupp, L. B. AU - Becker, D. J. PY - 2008 DA - 2008// TI - Abnormal T-cell reactivities in childhood inflammatory demyelinating disease and type 1 diabetes JO - Ann Neurol VL - 63 UR - https://doi.org/10.1002/ana.21244 DO - 10.1002/ana.21244 ID - Banwell2008 ER - TY - JOUR AU - McLaughlin, K. A. AU - Chitnis, T. AU - Newcombe, J. AU - Franz, B. AU - Kennedy, J. AU - McArdel, S. PY - 2009 DA - 2009// TI - Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis JO - J Immunol VL - 183 UR - https://doi.org/10.4049/jimmunol.0801888 DO - 10.4049/jimmunol.0801888 ID - McLaughlin2009 ER - TY - JOUR AU - Brilot, F. AU - Dale, R. C. AU - Selter, R. C. AU - Grummel, V. AU - Kalluri, S. R. AU - Aslam, M. PY - 2009 DA - 2009// TI - Antibodies to native myelin oligodendrocyte glycoprotein in children with inflammatory demyelinating central nervous system disease JO - Ann Neurol VL - 66 UR - https://doi.org/10.1002/ana.21916 DO - 10.1002/ana.21916 ID - Brilot2009 ER - TY - JOUR AU - O'Connor, K. C. AU - Lopez-Amaya, C. AU - Gagne, D. AU - Lovato, L. AU - Moore-Odom, N. H. AU - Kennedy, J. PY - 2010 DA - 2010// TI - Anti-myelin antibodies modulate clinical expression of childhood multiple sclerosis JO - J Neuroimmunol VL - 223 UR - https://doi.org/10.1016/j.jneuroim.2010.02.019 DO - 10.1016/j.jneuroim.2010.02.019 ID - O'Connor2010 ER - TY - JOUR AU - Horellou, P. AU - Wang, M. AU - Keo, V. AU - Chretien, P. AU - Serguera, C. AU - Waters, P. PY - 2015 DA - 2015// TI - Increased interleukin-6 correlates with myelin oligodendrocyte glycoprotein antibodies in pediatric monophasic demyelinating diseases and multiple sclerosis JO - J Neuroimmunol VL - 289 UR - https://doi.org/10.1016/j.jneuroim.2015.10.002 DO - 10.1016/j.jneuroim.2015.10.002 ID - Horellou2015 ER - TY - JOUR AU - Polman, C. H. AU - Reingold, S. C. AU - Banwell, B. AU - Clanet, M. AU - Cohen, J. A. AU - Filippi, M. PY - 2011 DA - 2011// TI - Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria JO - Ann Neurol VL - 69 UR - https://doi.org/10.1002/ana.22366 DO - 10.1002/ana.22366 ID - Polman2011 ER - TY - JOUR AU - Krupp, L. B. AU - Tardieu, M. AU - Amato, M. P. AU - Banwell, B. AU - Chitnis, T. AU - Dale, R. C. PY - 2013 DA - 2013// TI - International Pediatric Multiple Sclerosis Study Group criteria for pediatric multiple sclerosis and immune-mediated central nervous system demyelinating disorders: revisions to the 2007 definitions JO - Mult Scler VL - 19 UR - https://doi.org/10.1177/1352458513484547 DO - 10.1177/1352458513484547 ID - Krupp2013 ER - TY - JOUR AU - Benedetti, F. AU - Massa, M. AU - Robbioni, P. AU - Ravelli, A. AU - Burgio, G. R. AU - Martini, A. PY - 1991 DA - 1991// TI - Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis JO - Arthritis Rheum VL - 34 UR - https://doi.org/10.1002/art.1780340912 DO - 10.1002/art.1780340912 ID - Benedetti1991 ER - TY - JOUR AU - Tan, Z. AU - Yuan, Y. AU - Chen, S. AU - Chen, Y. AU - Chen, T. X. PY - 2013 DA - 2013// TI - Plasma Endothelial Microparticles, TNF-a and IL-6 in Kawasaki Disease JO - Indian Pediatr VL - 50 UR - https://doi.org/10.1007/s13312-013-0152-7 DO - 10.1007/s13312-013-0152-7 ID - Tan2013 ER - TY - JOUR AU - Wine, E. AU - Mack, D. R. AU - Hyams, J. AU - Otley, A. R. AU - Markowitz, J. AU - Crandall, W. V. PY - 2013 DA - 2013// TI - Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis JO - J Crohns Colitis VL - 7 UR - https://doi.org/10.1016/j.crohns.2012.12.012 DO - 10.1016/j.crohns.2012.12.012 ID - Wine2013 ER - TY - JOUR AU - Frampton, J. E. PY - 2013 DA - 2013// TI - Tocilizumab: a review of its use in the treatment of juvenile idiopathic arthritis JO - Paediatr Drugs VL - 15 UR - https://doi.org/10.1007/s40272-013-0053-1 DO - 10.1007/s40272-013-0053-1 ID - Frampton2013 ER - TY - JOUR AU - Eugster, H. P. AU - Frei, K. AU - Kopf, M. AU - Lassmann, H. AU - Fontana, A. PY - 1998 DA - 1998// TI - IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis JO - Eur J Immunol VL - 28 UR - https://doi.org/3.0.CO;2-D DO - 3.0.CO;2-D ID - Eugster1998 ER - TY - JOUR AU - Gijbels, K. AU - Brocke, S. AU - Abrams, J. S. AU - Steinman, L. PY - 1995 DA - 1995// TI - Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation JO - Mol Med VL - 1 ID - Gijbels1995 ER - TY - JOUR AU - Diab, A. AU - Zhu, J. AU - Xiao, B. G. AU - Mustafa, M. AU - Link, H. PY - 1997 DA - 1997// TI - High IL-6 and low IL-10 in the central nervous system are associated with protracted relapsing EAE in DA rats JO - J Neuropathol Exp Neurol VL - 56 UR - https://doi.org/10.1097/00005072-199706000-00002 DO - 10.1097/00005072-199706000-00002 ID - Diab1997 ER - TY - JOUR AU - Dale, R. C. AU - Morovat, A. PY - 2003 DA - 2003// TI - Interleukin-6 and oligoclonal IgG synthesis in children with acute disseminated encephalomyelitis JO - Neuropediatrics VL - 34 UR - https://doi.org/10.1055/s-2003-41281 DO - 10.1055/s-2003-41281 ID - Dale2003 ER - TY - JOUR AU - Ishizu, T. AU - Minohara, M. AU - Ichiyama, T. AU - Kira, R. AU - Tanaka, M. AU - Osoegawa, M. PY - 2006 DA - 2006// TI - CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis JO - J Neuroimmunol VL - 175 UR - https://doi.org/10.1016/j.jneuroim.2006.03.020 DO - 10.1016/j.jneuroim.2006.03.020 ID - Ishizu2006 ER - TY - JOUR AU - Janssens, K. AU - Slaets, H. AU - Hellings, N. PY - 2015 DA - 2015// TI - Immunomodulatory properties of the IL-6 cytokine family in multiple sclerosis JO - Ann N Y Acad Sci VL - 1351 UR - https://doi.org/10.1111/nyas.12821 DO - 10.1111/nyas.12821 ID - Janssens2015 ER - TY - JOUR AU - Rothaug, M. AU - Becker-Pauly, C. AU - Rose-John, S. PY - 2016 DA - 2016// TI - The role of interleukin-6 signaling in nervous tissue JO - Biochim Biophys Acta VL - 1863 UR - https://doi.org/10.1016/j.bbamcr.2016.03.018 DO - 10.1016/j.bbamcr.2016.03.018 ID - Rothaug2016 ER - TY - JOUR AU - Frisdal, E. AU - Lesnik, P. AU - Olivier, M. AU - Robillard, P. AU - Chapman, M. J. AU - Huby, T. PY - 2011 DA - 2011// TI - Interleukin-6 protects human macrophages from cellular cholesterol accumulation and attenuates the proinflammatory response JO - J Biol Chem VL - 286 UR - https://doi.org/10.1074/jbc.M111.264325 DO - 10.1074/jbc.M111.264325 ID - Frisdal2011 ER - TY - JOUR AU - Calabresi, P. A. AU - Tranquill, L. R. AU - Dambrosia, J. M. AU - Stone, L. A. AU - Maloni, H. AU - Bash, C. N. PY - 1997 DA - 1997// TI - Increases in soluble VCAM-1 correlate with a decrease in MRI lesions in multiple sclerosis treated with interferon beta-1b JO - Ann Neurol VL - 41 UR - https://doi.org/10.1002/ana.410410517 DO - 10.1002/ana.410410517 ID - Calabresi1997 ER - TY - JOUR AU - Rieckmann, P. AU - Altenhofen, B. AU - Riegel, A. AU - Baudewig, J. AU - Felgenhauer, K. PY - 1997 DA - 1997// TI - Soluble adhesion molecules (sVCAM-1 and sICAM-1) in cerebrospinal fluid and serum correlate with MRI activity in multiple sclerosis JO - Ann Neurol VL - 41 UR - https://doi.org/10.1002/ana.410410307 DO - 10.1002/ana.410410307 ID - Rieckmann1997 ER - TY - JOUR AU - Matsuda, M. AU - Tsukada, N. AU - Miyagi, K. AU - Yanagisawa, N. PY - 1995 DA - 1995// TI - Increased levels of soluble vascular cell adhesion molecule-1 (VCAM-1) in the cerebrospinal fluid and sera of patients with multiple sclerosis and human T lymphotropic virus type-1-associated myelopathy JO - J Neuroimmunol VL - 59 UR - https://doi.org/10.1016/0165-5728(95)00023-U DO - 10.1016/0165-5728(95)00023-U ID - Matsuda1995 ER - TY - JOUR AU - Rieckmann, P. AU - Kruse, N. AU - Nagelkerken, L. AU - Beckmann, K. AU - Miller, D. AU - Polman, C. PY - 2005 DA - 2005// TI - Soluble vascular cell adhesion molecule (VCAM) is associated with treatment effects of interferon beta-1b in patients with secondary progressive multiple sclerosis JO - J Neurol VL - 252 UR - https://doi.org/10.1007/s00415-005-0681-7 DO - 10.1007/s00415-005-0681-7 ID - Rieckmann2005 ER - TY - JOUR AU - Graber, J. AU - Zhan, M. AU - Ford, D. AU - Kursch, F. AU - Francis, G. AU - Bever, C. PY - 2005 DA - 2005// TI - Interferon-beta-1a induces increases in vascular cell adhesion molecule: implications for its mode of action in multiple sclerosis JO - J Neuroimmunol VL - 161 UR - https://doi.org/10.1016/j.jneuroim.2004.11.017 DO - 10.1016/j.jneuroim.2004.11.017 ID - Graber2005 ER - TY - JOUR AU - Bitsch, A. AU - Bahner, D. AU - Wachter, C. AU - Elitok, E. AU - Bogumil, T. AU - Dressel, A. PY - 2004 DA - 2004// TI - Interferon beta-1b modulates serum sVCAM-1 levels in primary progressive multiple sclerosis JO - Acta Neurol Scand VL - 110 UR - https://doi.org/10.1111/j.1600-0404.2004.00347.x DO - 10.1111/j.1600-0404.2004.00347.x ID - Bitsch2004 ER - TY - JOUR AU - Hong, J. AU - Hutton, G. J. PY - 2010 DA - 2010// TI - Regulatory effects of interferon-beta on osteopontin and interleukin-17 expression in multiple sclerosis JO - J Interferon Cytokine Res VL - 30 UR - https://doi.org/10.1089/jir.2010.0082 DO - 10.1089/jir.2010.0082 ID - Hong2010 ER - TY - JOUR AU - Mahon, B. D. AU - Gordon, S. A. AU - Cruz, J. AU - Cosman, F. AU - Cantorna, M. T. PY - 2003 DA - 2003// TI - Cytokine profile in patients with multiple sclerosis following vitamin D supplementation JO - J Neuroimmunol VL - 134 UR - https://doi.org/10.1016/S0165-5728(02)00396-X DO - 10.1016/S0165-5728(02)00396-X ID - Mahon2003 ER - TY - JOUR AU - Mosayebi, G. AU - Ghazavi, A. AU - Ghasami, K. AU - Jand, Y. AU - Kokhaei, P. PY - 2011 DA - 2011// TI - Therapeutic effect of vitamin D3 in multiple sclerosis patients JO - Immunol Invest VL - 40 UR - https://doi.org/10.3109/08820139.2011.573041 DO - 10.3109/08820139.2011.573041 ID - Mosayebi2011 ER - TY - JOUR AU - Mann, E. H. AU - Chambers, E. S. AU - Chen, Y. H. AU - Richards, D. F. AU - Hawrylowicz, C. M. PY - 2015 DA - 2015// TI - 1alpha,25-dihydroxyvitamin D3 acts via transforming growth factor-beta to up-regulate expression of immunosuppressive CD73 on human CD4+ Foxp3- T cells JO - Immunology VL - 146 UR - https://doi.org/10.1111/imm.12519 DO - 10.1111/imm.12519 ID - Mann2015 ER - TY - JOUR AU - Cantorna, M. T. AU - Woodward, W. D. AU - Hayes, C. E. AU - DeLuca, H. F. PY - 1998 DA - 1998// TI - 1,25-dihydroxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-beta 1 and IL-4 JO - J Immunol VL - 160 ID - Cantorna1998 ER - TY - JOUR AU - Racke, M. K. AU - Cannella, B. AU - Albert, P. AU - Sporn, M. AU - Raine, C. S. AU - McFarlin, D. E. PY - 1992 DA - 1992// TI - Evidence of endogenous regulatory function of transforming growth factor-beta 1 in experimental allergic encephalomyelitis JO - Int Immunol VL - 4 UR - https://doi.org/10.1093/intimm/4.5.615 DO - 10.1093/intimm/4.5.615 ID - Racke1992 ER - TY - JOUR AU - Mokhtarian, F. AU - Shi, Y. AU - Shirazian, D. AU - Morgante, L. AU - Miller, A. AU - Grob, D. PY - 1994 DA - 1994// TI - Defective production of anti-inflammatory cytokine, TGF-beta by T cell lines of patients with active multiple sclerosis JO - J Immunol VL - 152 ID - Mokhtarian1994 ER - TY - JOUR AU - Shirvani-Farsani, Z. AU - Behmanesh, M. AU - Mohammadi, S. M. AU - Naser, M. A. PY - 2015 DA - 2015// TI - Vitamin D levels in multiple sclerosis patients: Association with TGF-beta2, TGF-betaRI, and TGF-betaRII expression JO - Life Sci VL - 134 UR - https://doi.org/10.1016/j.lfs.2015.05.017 DO - 10.1016/j.lfs.2015.05.017 ID - Shirvani-Farsani2015 ER - TY - JOUR AU - Vargas-Lowy, D. AU - Kivisakk, P. AU - Gandhi, R. AU - Raddassi, K. AU - Soltany, P. AU - Gorman, M. P. PY - 2013 DA - 2013// TI - Increased Th17 response to myelin peptides in pediatric MS JO - Clin Immunol VL - 146 UR - https://doi.org/10.1016/j.clim.2012.12.008 DO - 10.1016/j.clim.2012.12.008 ID - Vargas-Lowy2013 ER - TY - JOUR AU - O'Regan, A. AU - Berman, J. S. PY - 2000 DA - 2000// TI - Osteopontin: a key cytokine in cell-mediated and granulomatous inflammation JO - Int J Exp Pathol VL - 81 UR - https://doi.org/10.1046/j.1365-2613.2000.00163.x DO - 10.1046/j.1365-2613.2000.00163.x ID - O'Regan2000 ER - TY - JOUR AU - Ashkar, S. AU - Weber, G. F. AU - Panoutsakopoulou, V. AU - Sanchirico, M. E. AU - Jansson, M. AU - Zawaideh, S. PY - 2000 DA - 2000// TI - Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity JO - Science VL - 287 UR - https://doi.org/10.1126/science.287.5454.860 DO - 10.1126/science.287.5454.860 ID - Ashkar2000 ER - TY - JOUR AU - Jansson, M. AU - Panoutsakopoulou, V. AU - Baker, J. AU - Klein, L. AU - Cantor, H. PY - 2002 DA - 2002// TI - Cutting edge: Attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin-deficient mice JO - J Immunol VL - 168 UR - https://doi.org/10.4049/jimmunol.168.5.2096 DO - 10.4049/jimmunol.168.5.2096 ID - Jansson2002 ER - TY - JOUR AU - Braitch, M. AU - Nunan, R. AU - Niepel, G. AU - Edwards, L. J. AU - Constantinescu, C. S. PY - 2008 DA - 2008// TI - Increased osteopontin levels in the cerebrospinal fluid of patients with multiple sclerosis JO - Arch Neurol VL - 65 UR - https://doi.org/10.1001/archneur.65.5.633 DO - 10.1001/archneur.65.5.633 ID - Braitch2008 ER - TY - JOUR AU - Comabella, M. AU - Pericot, I. AU - Goertsches, R. AU - Nos, C. AU - Castillo, M. AU - Blas Navarro, J. PY - 2005 DA - 2005// TI - Plasma osteopontin levels in multiple sclerosis JO - J Neuroimmunol VL - 158 UR - https://doi.org/10.1016/j.jneuroim.2004.09.004 DO - 10.1016/j.jneuroim.2004.09.004 ID - Comabella2005 ER -