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Table 2 Anatomo-clinical correlation and diagnosis details

From: The still under-investigated role of cognitive deficits in PML diagnosis

  Lesion site Cognitive deficit Anatomo clinical correlation How symptoms were detected Neuropsychological tests
1 L_Parietal Verbal memory X Patient’s complain + formal NPS assessment N/A
2 L_Tempo Parietal Language and reading deficits X Evident at neurological examination -
3 L_Cerebellum Language deficit, dementia, apraxia - Patient’s complain + formal NPS assessment Mini mental state examination; Language test, apraxia test, drawing test
4 L_Temporal Aphasia X Evident at neurological examination + formal NPS assessment N/A
5 Bilateral Fronto temporo and Parietal Spatial and temporal disorientation + perseveration + apraxia + left neglect X Patient’s complain + formal NPS assessment Mini mental state examination for disorientation; Apraxia test; drawing test; Verbal fluency; Line bisection
6 L_Parieto occipital Right neglect Objects’ Agnosia X Patient’s complain + formal NPS assessment Line bisection; Apraxia test; Agnosia test
7 R_ Fronto temporal Memory deficit Disorientation X Patient’s complain -
8 L_Insula, ippocampus and parahippocampus (temporal lobe) Memory deficit X Patient’s complain + formal NPS assessment N/A
9 L_Parieto-temporal occipital Anomia + semantic paraphasias X Patient’s complain + formal NPS assessment Verbal fluency
10 L_Temporo occipital Aphasia, reading difficulties X Patient’s complain + Evident at neurological examination -
11 L_Temporo parietal Aphasia, acalculia, apraxia, agraphia X Patient’s complain + formal NPS assessment Aachener Aphasia test; Apraxia test; drawing test; acalculia test
12 L_ Thalamus Memory X formal NPS assessment N/A
13a R_Fronto-temporo occipital Memory and attention X formal NPS assessment N/A
  1. For each patient is reported: the PML lesion site, the type of cognitive deficits manifested and /or complained by the patients, the possible anatomo clinical correlation between the lesion site and the neuropsychological difficulties and how the symptoms have been diagnosed. athe MRI is missing (neuroradiological report provided). L left, R right, NPS neuropsychological, N/A not available