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Table 2 Anatomo-clinical correlation and diagnosis details

From: The still under-investigated role of cognitive deficits in PML diagnosis

 

Lesion site

Cognitive deficit

Anatomo clinical correlation

How symptoms were detected

Neuropsychological tests

1

L_Parietal

Verbal memory

X

Patient’s complain + formal NPS assessment

N/A

2

L_Tempo Parietal

Language and reading deficits

X

Evident at neurological examination

-

3

L_Cerebellum

Language deficit, dementia, apraxia

-

Patient’s complain + formal NPS assessment

Mini mental state examination; Language test, apraxia test, drawing test

4

L_Temporal

Aphasia

X

Evident at neurological examination + formal NPS assessment

N/A

5

Bilateral Fronto temporo and Parietal

Spatial and temporal disorientation + perseveration + apraxia + left neglect

X

Patient’s complain + formal NPS assessment

Mini mental state examination for disorientation; Apraxia test; drawing test; Verbal fluency; Line bisection

6

L_Parieto occipital

Right neglect Objects’ Agnosia

X

Patient’s complain + formal NPS assessment

Line bisection; Apraxia test; Agnosia test

7

R_ Fronto temporal

Memory deficit Disorientation

X

Patient’s complain

-

8

L_Insula, ippocampus and parahippocampus (temporal lobe)

Memory deficit

X

Patient’s complain + formal NPS assessment

N/A

9

L_Parieto-temporal occipital

Anomia + semantic paraphasias

X

Patient’s complain + formal NPS assessment

Verbal fluency

10

L_Temporo occipital

Aphasia, reading difficulties

X

Patient’s complain + Evident at neurological examination

-

11

L_Temporo parietal

Aphasia, acalculia, apraxia, agraphia

X

Patient’s complain + formal NPS assessment

Aachener Aphasia test; Apraxia test; drawing test; acalculia test

12

L_ Thalamus

Memory

X

formal NPS assessment

N/A

13a

R_Fronto-temporo occipital

Memory and attention

X

formal NPS assessment

N/A

  1. For each patient is reported: the PML lesion site, the type of cognitive deficits manifested and /or complained by the patients, the possible anatomo clinical correlation between the lesion site and the neuropsychological difficulties and how the symptoms have been diagnosed. athe MRI is missing (neuroradiological report provided). L left, R right, NPS neuropsychological, N/A not available