Fig. 3
From: Methylthioadenosine promotes remyelination by inducing oligodendrocyte differentiation
Methylthioadenosine increases the number of mature myelinating OLs in mouse cerebellar cultures. a Effect of methylthioadenosine (MTA, 192μM) treatment before lysolecithin induced demyelination. Olig2/MBP staining was used as a marker of mature OLs: Grey, control tissue (no lysolecithin); White, lysolecithin challenged tissue treated with MTA at different time points (9, 13 and 17 DIV); Black, lysolecithin challenged tissue treated with the placebo. b Effect of MTA (192μM) on mature myelinating OLs after lysolecithin induced demyelination: Grey, control tissue without lysolecithin; White, lysolecithin tissue treated with MTA; Black, lysolecithin tissue treated with placebo at different time points (9, 13 and 17 DIV). Results are the mean of three independent experiments with six slices per condition in each experiment. * p ≤ 0.05; **p ≤ 0.01 and ***p ≤ 0.001 with respect to the placebo; & p ≤ 0.01 relative to the controls