Fig. 4

The MOG35-55 peptides. a Location of the segment 35–55 in the MOG Ig domain crystal structure [58]. Shown (as sticks) are also the glycosylation site Asn31 [101] and the Ser42 residue (at the hairpin of the MOG35-55 epitope), which when mutated to Pro, as in human MOG, produces a less encephalitogenic response [57]. b SRCD spectra of the human (top) and mouse (bottom) MOG35-55 peptides in the absence and presence of lipid vesicles. Similar results were also obtained in conventional CD at P/L ratios of 1:30 and 1:100. c TFE titration of the human (left) and mouse (right) peptides. d DPC titration. e SDS titration. Note the different behaviour of both peptides below and above the CMC