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Fig. 5 | Multiple Sclerosis and Demyelinating Disorders

Fig. 5

From: Myelin-derived and putative molecular mimic peptides share structural properties in aqueous and membrane-like environments

Fig. 5

Peptide epitopes from MOBP. a Predicted structure of the FYVE-like domain at the N terminus of MOBP. The regions corresponding to the peptides studied here are coloured, and potential metal ion-coordinating residues (Cys/His) are shown as sticks. b Predicted interaction [38] of the model with a membrane surface. c TFE titration of MOBP15-36 (left) and MOBP37-60 (right). d DPC titration. e SDS titration. Note the different behaviour below and above the CMC. f SRCD spectra in the absence and presence of DMPC/DMPG vesicles. The MOBP37-60 peptide has pronounced beta content, while MOBP15-36 is more helical

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Multiple Sclerosis and Demyelinating Disorders

ISSN: 2056-6115

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