Skip to main content
Fig. 6 | Multiple Sclerosis and Demyelinating Disorders

Fig. 6

From: Myelin-derived and putative molecular mimic peptides share structural properties in aqueous and membrane-like environments

Fig. 6

PLP-derived peptides. a Schematic structure of PLP. The peptide colouring is shown in the legend, and the segment missing in DM20 is shown by red sequence. Potential palmitoylation sites are also indicated. b Helical wheel of a predicted amphipathic helix in the PLPintra2 (and PLP139-151) peptide. c Predicted membrane association of the C-terminal half of the PLPintra2 peptide, based on the PEP-FOLD model. d Behaviour of PLP peptides in membrane-mimicking conditions. From left to right: typical spectra for a TFE titration series (shown here for the PLPintra1 peptide), relative signals at 195 nm in the presence of TFE, DPC, and SDS for all peptides. e Conventional CD spectra of the PLP peptides (left to right: PLPintra1, PLPintra2, PLP139-151, PLPextra2) at different P/L ratios in the presence of DMPC/DMPG vesicles

Back to article page