Myelin-derived and putative molecular mimic peptides share structural properties in aqueous and membrane-like environments

Table 1 The peptides selected for the current study

Peptide	Sequence	Predicted structure	References
MOBP15-36	QKFSEHFSIHCCPPFTFLNSKR	beta/disordered	[7]
MOBP37-60	EIVDRKYSICKSGCFYQKKEEDWI	alpha/disordered	[8]
hMOG35-55	MEVGWYRPPFSRVVHLYRNGK	beta/disordered	[6]
mMOG35-55	MEVGWYRSPFSRVVHLYRNGK	beta/disordered	[6]
HSV-mimic	FRQLVHFVRDFAQLL	alpha	[19]
EB-mimic	TGGVYHFVKKHVHES	alpha	[19]
IA-mimic	YRNLVWFIKKNTRYP	beta/disordered	[19]
PA-mimic	DRLLMLFAKDVVSRN	alpha	[19]
P2gbs	ENFDDYMKALGV	alpha/disordered	[78]
PLP139-151	VSLGKWLGHPDKF	alpha/disordered	[4]
PLPextra2	FNTWTTCQSIAFPSKTSASIGSLCADARMYG	alpha/disordered	[5, 60]
PLPintra1	AEGFYTTGAVEQIFGDYKTTICGKGLSATVTGGQKGRG	mixed	[60, 100]
PLPintra2	SRGQHQAHSLERVCHCLGKWLGHPDKFVGI	alpha/disordered	[4, 60]

The predicted structure corresponds to that obtained from PEP-FOLD. References for the possible disease linkage of each peptide are also given

ISSN: 2056-6115