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Table 4 Diagnostic alternatives in relation to clinical evolution (from ref [1], modified)

From: Pediatric versus adult MS: similar or different?

ONSET CONSIDER also
Hyperacute - Vascular disorders
- Trauma
- Toxic/infectious aetiologies
Acute or subacute - Infectious aetiologies
- Vascular/reumatological diseases
- Malignancies
- Macrophage-activation syndrome
Insidious, progressive - Inherited metabolic disorders
- Nutritional deficiencies (B12)
- Vascular disorders