Case scenario, questions and answers | Overall (n = 205) | Sub-group by the number of MS patients under care | P value | |||
---|---|---|---|---|---|---|
Group 1: 1–3 patients (n = 69) | Group 2: 4–9 patients (n = 58) | Group 3: ≥10 patients (n = 78) | Group comparison*,† | Trend test‡ | ||
Case 1: A 25-year-old man with RRMS and 2 clinical relapses in the last 4 years is treatment naïve and presents with a normal neurologic exam. A recent MRI reveals 5 non-enhancing T2 lesions in the brain. | ||||||
Question 1: Would you initiate DMD# treatment? | ||||||
Yes, n (%) | 187 (91.2) | 63 (91.3) | 53 (91.4) | 71 (91.0) | 0.988a 0.953b 0.943c | 0.951 |
Question 2: If you answered yes in Question 1, when would you perform the follow-up MRI? | ||||||
Follow-up timing, n/187 (%) § | ||||||
≤ 3 months | 62 (33.2) | 22 (34.9) | 17 (32.7) | 23 (32.4) | 0.480a 0.331b 0.197c | 0.657 |
> 3– ≤6 months | 98 (52.4) | 31 (49.2) | 25 (48.1) | 42 (59.2) | ||
> 6– ≤12 months | 24 (12.8) | 10 (15.9) | 8 (15.1) | 6 (8.5) | ||
> 12 months | 2 (1.1) | 0 (0.0) | 2 (3.8) | 0 (0.0) | ||
Case 2: Assume that you are presented with the Case 1 patient with RRMS who remains as treatment naïve and has had 2 clinical relapses in close proximity (last 6 months) that have left him with a residual disability. MRI reveals multiple, extensive, non-enhancing T2 lesions in the brain, brainstem, and spinal cord. | ||||||
Question 3: Would you initiate DMD# treatment? | ||||||
Yes, n (%) | 198 (96.6) | 65 (94.2) | 57 (98.3) | 76 (97.4) | 0.240a 0.323b 0.742c | 0.294 |
Case 3: Assume that you are presented with the Case 1 patient with RRMS who remains as treatment naïve and has had 2 clinical relapses in close proximity (last 6 months) that have left him with residual disability. MRI shows multiple, extensive, non-enhancing T2 lesions in the brain, brainstem, and spinal cord; multiple T1 hypointense lesions; and brain atrophy. | ||||||
Question 4: Following initiation of therapy, when would you perform a follow-up MRI? | ||||||
Follow-up timing, n/205 (%) | ||||||
≤ 3 months | 95 (46.3) | 36 (52.2) | 24 (41.4) | 35 (44.9) | 0.200a 0.626b 0.411c | 0.400 |
> 3– ≤6 months | 86 (42.0) | 28 (40.6) | 23 (39.7) | 35 (44.9) | ||
> 6– ≤12 months | 23 (11.2) | 5 (7.2) | 10 (17.2) | 8 (10.3) | ||
> 12 months | 1 (0.5) | 0 (0.0) | 1 (1.7) | 0 (0.0) |